University of Florida origins. Global potential.
Originally housed at the University of Florida's award-winning Sid Martin Biotech Incubator (2012-2015), Prometheon Pharma's patented Topicon™ transdermal technology is poised to make a global impact with convenient, affordable, biodegradable extended-wear drug patches that require little refrigeration. These patches are simple and inexpensive enough to help address global pandemics and provide better delivery alternatives for orphan disease treatments alike. On the foundation of this platform technology, Prometheon seeks to build a socially responsible and globally oriented pharmaceutical and biotechnology company, comprised of ethically conscious individuals of diverse talents, creating innovative solutions for the world's greatest threats to health and humanity.
Stephen Hsu, MD, PhD, Founder, CEO/CSO, and Board Member
Stephen Hsu is a Harvard-trained, internationally acclaimed physician-scientist with a passion for patient engagement and global health solutions through the application of clinical translational research. Steve has several patents to his name with previous products commercialized from nearly two decades of characterizing the TRIP-Br family of proteins he discovered during his clinical fellowship at the Massachusetts General Hospital. They function as regulators of the cell cycle, turning genes on and off, as well as playing the role of a master regulator of the balance between fat utilization vs. storage. These master regulators of metabolism are now therapeutic targets for developing a novel class of anti-obesity drugs. Steve was recruited from the Brigham & Women's Hospital (Harvard Medical School) to be the first occupant of the R. Glenn Davis Endowed Chair in Clinical and Translational Medicine in the Division of Nephrology and Director of the MD-PhD Training Program at the University of Florida in 2007.
In the fall of 2012, Steve left academia to focus his efforts full-time on commercializing his invention of Topicon™, specifically developed to enable the passive transdermal delivery of peptide drugs such as insulin. His list of candidate large and small molecule drugs that would be ideally delivered in the embodiment of extended-wear TruePatch™ products grows daily. Steve is also spearheading the development of a novel class of anti-obesity drugs based on his research group's January 2013 co-publication in Nature Medicine with international collaborators including the Joslin Diabetes Center (Harvard Medical School) to address the global pandemic of obesity and type 2 diabetes.
Steve is a life-long practitioner of Japanese zen archer (Kyudo) and swordsmanship (Iaido).
Hua Yao, PhD, Director of Research and Development
Hua Yao brings an extensive background in medicinal chemistry, pharmaceutics, and transdermal drug formulation. She oversees the conception, execution, and technical evaluation of studies for our in-house new product development program as well as for our industry and academic partners. Hua received her Ph.D. in medicinal chemistry from the University of Florida in 2007 with a focus on anti-cancer and orphan drug development and delivery methods. Subsequently, she completed two NIH-funded postdoctoral fellowships to expand her research areas in histopathology of degenerative CNS diseases and pharmacodynamics of anti-obesity peptide drugs.
Helen Goh, BA, Director of Marketing and Communications
Helen Goh brings 18 years of advertising account management and global strategic development experience from agencies including Euro RSCG (Havas), DDB Needham (Omicom), and Dentsu Young and Rubicam (WPP). She served as Group Account Director for major accounts such as Intel, Citibank and Chase. In other marketing roles, Helen has worked for Turner Broadcasting Corp , Chinadotcom Corp, and McDonald’s Corp’s Pret A Manger.
Helen received her BA in sociology from the National University of Singapore and is currently the Director of Marketing and Communications (College of Engineering) at the University of Florida. Helen Goh and Dr. Stephen Hsu are married.
BOARD OF MANAGERS
Frank M. Silver, PhD, Chairman of the Board
Frank Silver is a highly accomplished former industry executive and entrepreneur who brings with him a wealth of experience in leadership and business spanning over four decades. Frank has a deep knowledge of new product develop through the commercialization of technology with companies, academia, and governments, based on his long career at Monsanto. After retiring and remaining in Pensacola, FL, he founded a successful consulting company (Silver Consulting, International). Frank earned his BSc in Chemistry from the University of North Carolina-Chapel Hill, followed by pre-doctoral research on conversion of squalene to cholesterol for which he was conferred his PhD in Organic Chemistry from the University of Wisconsin-Madison in 1970. As a material science expert, he is advising Dr. Hsu and established patch development/manufacturing companies towards the prototyping to commercial form of the Topicon™ ThermoMatrix™ design, which will set a new industry standard. He is also co-inventor with Dr. Hsu of a completely heat-resistant transdermal patch (HeatWave™) for the delivery of perishable peptide and protein drugs in equatorial regions of the world.
Richard Miles, BA, MS, Board Member
Richard Miles is co-founder and Vice President of the Cade Museum for Creativity and Invention in Gainesville, Florida. The mission of the Cade Museum, a non-profit "startup" that opened in late 2015, is to inspire creative thinking, future inventors, and early entrepreneurs. He received a BA in Russian Studies from the University of Washington in 1987, and an MSc in Foreign Service from Georgetown University in 1993. He is fluent in Spanish and German. Prior to joining the Cade Museum, Richard was a career Foreign Service Officer with the US Department of State. From 2006-2008, Richard worked at the White House on the National Security Council (NSC) as Director for North America and as the Executive Assistant Director to the Deputy National Security Advisor. From 2008 to 2009, he served as a civilian adviser on a Provincial Reconstruction Team in Karbala, Iraq. Prior to the NSC, he had a variety of diplomatic assignments abroad, including Argentina, Germany, and Barbados. Before entering the Foreign Service, Richard was an intelligence officer in the US Army, stationed with the Second Armored Cavalry Regiment (ACR) in Nuremberg, Germany from 1988 to 1991. He participated in Operations Desert Shield and Desert Storm in 1991. Richard serves as Prometheon’s liaison to advocacy groups, lobbyists, and government agencies, domestic and foreign. He is married to Phoebe Cade-Miles, President and CEO of the Cade Museum, and daughter of the late great Professor Robert "Bob" Cade--the inventor of Gatorade while a faculty member in the Division of Nephrology at the University of Florida.